Thomas, L. L., van der Vegt, S. A., & Fromme, J. C. A steric gating mechanism dictates the substrate specificity of a Rab-GEF. Dev. Cell. 2019 Jan. 7;48(1):100-114.
Halaby, S.L. and Fromme, J.C. The HUS-box is required for allosteric regulation of the Sec7 Arf-GEF. J. Biol. Chem. 2018 May 4;293(18):6682-6691.
*Thomas, L.L., *Joiner, A.M.N., and Fromme, J.C. The TRAPPIII complex activates the GTPase Ypt1 (Rab1) in the secretory pathway. J. Cell Biol. 2018 Jan 2;217(1):283-298.
Gustafson, M.A. and Fromme, J.C. Regulation of Arf activation occurs via distinct mechanisms at early and late Golgi compartments. Mol. Biol. Cell 2017 Dec 1;28(25):3660-3671.
Thomas, L.L., and Fromme, J.C. GTPase cross talk regulates TRAPPII activation of Rab11 homologues during vesicle biogenesis. J. Cell Biol. 2016 Nov 21;215(4):499-513.
Richardson, B.C., Halaby, S.L., Gustafson, M.A., and Fromme, J.C. The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase. eLife. 10.7554/eLife.12411.
McDonold, C.M., and Fromme, J.C. Four GTPases differentially regulate the Sec7 Arf-GEF to direct traffic at the trans-Golgi network. Dev. Cell. 2014 Sept 29; 30(6): 759-767.
Paczkowski, J.E., and Fromme, J.C. Structural basis for membrane binding and remodeling by the exomer secretory vesicle cargo adaptor. Dev. Cell. 2014 Sept 8; 30(5): 610-624.
Weiskoff, A.M., and Fromme, J.C. Distinct N-terminal regions of the exomer secretory vesicle cargo Chs3 regulate its trafficking itinerary. Front. Cell Dev. Biol.. 2014 Sept 3; 2: 10.3389/fcell.2014.00047.
Richardson BC, Fromme JC. The exomer cargo adaptor features a flexible hinge domain. Structure. 2013 Mar 5; 21(3):486-92. doi: 10.1016/j.str.2013.01.003. Epub 2013 Feb 7.
*Paczkowski JE, *Richardson BC, Strassner AM, Fromme JC. The exomer cargo adaptor structure reveals a novel GTPase-binding domain. EMBO J. 2012 Nov 5; 31(21):4191-203. doi: 10.1038/emboj.2012.268. Epub 2012 Sep 21.
Richardson BC, McDonold CM, Fromme JC. The Sec7 Arf-GEF is recruited to the trans-Golgi network by positive feedback. Dev Cell. 2012 Apr 17; 22(4):799-810. doi: 10.1016/j.devcel.2012.02.006.
Chris Fromme is an Associate Professor in the Weill Institute for Cell and Molecular Biology and the Department of Molecular Biology and Genetics. After graduating from Cornell with a B.A. in Biology in 1999, Chris did his graduate studies at Harvard University, receiving a Ph.D. in Biochemistry in 2004. He then did postdoctoral work as a Miller Institute Fellow at UC Berkeley, where he began his work on protein trafficking and membrane transport. He joined the Cornell faculty in 2008.