Chris Fromme, Ph.D.

Chris Fromme is an Associate Professor in the Weill Institute for Cell and Molecular Biology and the Department of Molecular Biology and Genetics. After graduating from Cornell with a B.A. in Biology in 1999, Chris did his graduate studies at Harvard University, receiving a Ph.D. in Biochemistry in 2004. He then did postdoctoral work as a Miller Institute Fellow at UC Berkeley, where he began his work on protein trafficking and membrane transport. He joined the Cornell faculty in 2008.

Chris Fromme, Ph.D
Weill Institute for Cell and Molecular Biology
Department of Molecular Biology and Genetics
Cornell University
457 Weill Hall
Ithaca, NY 14853-7202

(607)255-1016 (Office)
(607)255-7834 (Lab)

Selected Publications

Thomas, L. L., van der Vegt, S. A., & Fromme, J. C. A steric gating mechanism dictates the substrate specificity of a Rab-GEF. Dev. Cell. 2019 Jan. 7;48(1):100-114.

Halaby, S.L. and Fromme, J.C. The HUS-box is required for allosteric regulation of the Sec7 Arf-GEF. J. Biol. Chem. 2018 May 4;293(18):6682-6691.

*Thomas, L.L., *Joiner, A.M.N., and Fromme, J.C. The TRAPPIII complex activates the GTPase Ypt1 (Rab1) in the secretory pathway. J. Cell Biol. 2018 Jan 2;217(1):283-298.

Gustafson, M.A. and Fromme, J.C. Regulation of Arf activation occurs via distinct mechanisms at early and late Golgi compartments. Mol. Biol. Cell 2017 Dec 1;28(25):3660-3671.

Thomas, L.L., and Fromme, J.C. GTPase cross talk regulates TRAPPII activation of Rab11 homologues during vesicle biogenesis. J. Cell Biol. 2016 Nov 21;215(4):499-513.

Richardson, B.C., Halaby, S.L., Gustafson, M.A., and Fromme, J.C. The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase. eLife. 10.7554/eLife.12411.

McDonold, C.M., and Fromme, J.C. Four GTPases differentially regulate the Sec7 Arf-GEF to direct traffic at the trans-Golgi network.   Dev. Cell. 2014 Sept 29; 30(6): 759-767.

Paczkowski, J.E., and Fromme, J.C. Structural basis for membrane binding and remodeling by the exomer secretory vesicle cargo adaptor.   Dev. Cell. 2014 Sept 8; 30(5): 610-624.

Weiskoff, A.M., and Fromme, J.C. Distinct N-terminal regions of the exomer secretory vesicle cargo Chs3 regulate its trafficking itinerary.   Front. Cell Dev. Biol.. 2014 Sept 3; 2: 10.3389/fcell.2014.00047.

Richardson BC, Fromme JC. The exomer cargo adaptor features a flexible hinge domain.  Structure. 2013 Mar 5; 21(3):486-92. doi: 10.1016/j.str.2013.01.003. Epub 2013 Feb 7.

*Paczkowski JE, *Richardson BC, Strassner AM, Fromme JC. The exomer cargo adaptor structure reveals a novel GTPase-binding domain.  EMBO J. 2012 Nov 5; 31(21):4191-203. doi: 10.1038/emboj.2012.268. Epub 2012 Sep 21.

Richardson BC, McDonold CM, Fromme JC. The Sec7 Arf-GEF is recruited to the trans-Golgi network by positive feedback. Dev Cell. 2012 Apr 17; 22(4):799-810. doi: 10.1016/j.devcel.2012.02.006.

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