• October 2017: Steve Halaby has been awarded a Provost’s Diversity Fellowship. Congratulations, Steve!
  • October 2017: Laura and Aaron’s paper on the function of TRAPPIII at the Golgi has been accepted by JCB!
  • September 2017: Maggie’s paper on Gea1/2 has been accepted by MBoC!
  • September 2017: The Cornell Research website has done a profile on our lab.
  • August 2017: Steve Halaby has received the George P. Hess Travel Award. Congratulations, Steve!
  • August 2017: Carolyn passed her A-exam. Congratulations, Carolyn!!
  • May 2017: Graduate student Arnold Muccini joined the lab. Welcome Arnold!
  • May 2017: Laura Thomas won the LPS BMCB Best Paper award! (many thanks to Frank Meleca at LPS!)
  • May 2017: Carolyn Diefenderfer has been awarded an NSF Graduate Research Fellowship!
  • May 2017: Steve Halaby was awarded the Advanced Career Exemplary Service Award from the Cornell OISE!
  • May 2017: Laura Thomas won a poster award at the Canadian Society for Molecular Biosciences!
  • May 2017: Aaron was selected as the “BESTie of the month”!
  • April 2017: Visiting student Kelly Rosch presented her work at the CURB (Cornell Undergraduate Research Board) Spring Forum.
  • April 2017: Aaron Joiner and Steve Halaby were inducted into the Bouchet Honor Society!
  • March 2017: Carolyn Diefenderfer earned Honorable Mention in the NSF GRFP competition. Congratulations, Carolyn!
  • November 2016: Steve Halaby and Aaron Joiner have been selected to join the Bouchet Graduate Honor Society.
  • October 2016: Laura’s TRAPPII paper has been accepted for publication in the The Journal of Cell Biology!
  • October 2016: Several members of the Fromme Lab (Aaron, Carolyn, Maggie, and Steve) are involved in local outreach to elementary schools through their work with GRASSHOPR.
  • September 2016: Laura Thomas won a poster award at the FASEB GTPase meeting
  • August 2016: Laura Thomas was awarded the George P. Hess Travel Award. Congratulations, Laura!
  • July 2016: Aaron Joiner attended Cornell’s Future Professors Institute.
  • June 2016: Undergraduate student Solveig van der Vegt has been selected as a Hunter R. Rawlings III Cornell Presidential Scholar. Congratulations, Solveig!
  • April 2016: Steve Halaby goes to Washington!
  • April 2016: Maggie Gustafson was awarded the Harry and Samuel Mann Outstanding Graduate Student Award. Congratulations, Maggie!
  • April 2016: Chris was awarded a Guggenheim Fellowship for his upcoming sabbatical in Cambridge, UK.
  • March 2016: Cornell Chronicle article describing the efforts of Aaron and Steve as Graduate Student Ambassadors.
  • January 2016: Brian’s Sec7 structure paper has been accepted for publication in eLife!
  • December 2015: Chris has been selected as a Visiting Fellow at Clare Hall, Cambridge for his sabbatical in 2016.
  • September 2015: Steve Halaby passed his “A” exam!
  • July 2015: Chris and Brian attended the Molecular Membrane Gordon Conference to present a talk and a poster.
  • July 2015: Laura Thomas passed her “A” exam!
  • June 2015: Graduate student Aaron Joiner has joined the Fromme Lab. Welcome, Aaron!
  • May 2015: Chris Fromme is promoted to Associate Professor.
  • May 2015: Former graduate student Jon Paczkowski is awarded a Jane Coffin Childs postdoctoral fellowship.
  • May 2015: Former graduate student Jon Paczkowski is awarded the LPS Inc., “Best Paper” award.
  • April 2015: Graduate student Laura Thomas earns honorable mention in the NSF graduate research fellowship competition.
  • February 2015: Graduate student Maggie Gustafson is awarded the George P. Hess Travel Award.

Chris Fromme, Ph.D.

Chris Fromme is an Associate Professor in the Weill Institute for Cell and Molecular Biology and the Department of Molecular Biology and Genetics. After graduating from Cornell with a B.A. in Biology in 1999, Chris did his graduate studies at Harvard University, receiving a Ph.D. in Biochemistry in 2004. He then did postdoctoral work as a Miller Institute Fellow at UC Berkeley, where he began his work on protein trafficking and membrane transport. He joined the Cornell faculty in 2008.

Chris Fromme, Ph.D
Weill Institute for Cell and Molecular Biology
Department of Molecular Biology and Genetics
Cornell University
457 Weill Hall
Ithaca, NY 14853-7202

(607)255-1016 (Office)
(607)255-7834 (Lab)

Selected Publications

Thomas, L.L., and Fromme, J.C. GTPase cross talk regulates TRAPPII activation of Rab11 homologues during vesicle biogenesis. J. Cell Biol. 2016 Nov 21;215(4):499-513. doi: 10.1083/jcb.201608123.

Paczkowski, J.E. and Fromme, J.C. Analysis of Arf1 GTPase-Dependent Membrane Binding and Remodeling Using the Exomer Secretory Vesicle Cargo Adaptor. Methods Mol Biol. 2016;1496:41-53. doi: 10.1007/978-1-4939-6463-5_4.

Richardson, B.C., Halaby, S.L., Gustafson, M.A., and Fromme, J.C. The Sec7 N-terminal regulatory domains facilitate membrane-proximal activation of the Arf1 GTPase. eLife. 10.7554/eLife.12411.

Paczkowski, J.E., Richardson, B.C., and Fromme, J.C. Cargo adaptors: structures illuminate mechanisms regulating vesicle biogenesis. Trends Cell Biol. 10.1016/j.tcb.2015.02.005.

McDonold, C.M., and Fromme, J.C. Four GTPases differentially regulate the Sec7 Arf-GEF to direct traffic at the trans-Golgi network.   Dev. Cell. 2014 Sept 29; 30(6): 759-767.

Paczkowski, J.E., and Fromme, J.C. Structural basis for membrane binding and remodeling by the exomer secretory vesicle cargo adaptor.   Dev. Cell. 2014 Sept 8; 30(5): 610-624.

Weiskoff, A.M., and Fromme, J.C. Distinct N-terminal regions of the exomer secretory vesicle cargo Chs3 regulate its trafficking itinerary.   Front. Cell Dev. Biol.. 2014 Sept 3; 2: 10.3389/fcell.2014.00047.

Richardson BC, Fromme JC. The exomer cargo adaptor features a flexible hinge domain.  Structure. 2013 Mar 5; 21(3):486-92. doi: 10.1016/j.str.2013.01.003. Epub 2013 Feb 7.

Paczkowski JE, Richardson BC, Strassner AM, Fromme JC. The exomer cargo adaptor structure reveals a novel GTPase-binding domain.  EMBO J. 2012 Nov 5; 31(21):4191-203. doi: 10.1038/emboj.2012.268. Epub 2012 Sep 21.

Richardson BC, McDonold CM, Fromme JC. The Sec7 Arf-GEF is recruited to the trans-Golgi network by positive feedback. Dev Cell. 2012 Apr 17; 22(4):799-810. doi: 10.1016/j.devcel.2012.02.006.

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